Characterization of a Novel Col1a1 Osteogenesis Imperfecta Mouse Model with Insights into Skeletal Phenotype, Fragility, and Therapeutic Evaluations.

Osteogenesis imperfecta (OI) is an inheritable skeletal disorder characterized by bone fragility often caused by pathogenic variants in the COL1A1 gene. Current OI mouse models with a glycine substitution in Col1a1 exhibit excessive severity, thereby limiting long-term pathophysiological analysis and drug effect assessments. To address this limitation, we constructed a novel OI mouse model mimicking a patient with OI type III.

Comprehensive image quality comparison of conventional and new flat panel detectors under bedside chest radiography beam conditions.

Recently, a novel wireless flat-panel detector with auto-exposure control has become available. This study aimed to elucidate the potential advantages of the new detector over conventional detectors through a comprehensive analysis of the physical image quality characteristics. Measurements were conducted on two models: new (720C) and conventional (710C) versions; this assessment was performed by assuming the beam quality for bedside chest radiography, utilizing a portable device for X-ray exposure.

Usefulness of fat attenuation index in postmortem CT for identifying responsible vessels in acute coronary syndromes: A case report.

Postmortem imaging, particularly unenhanced postmortem computed tomography (PMCT), has been increasingly utilized for pathological or judicial examination as a substitute for conventional autopsy, to compensate very low autopsy rates. While unenhanced PMCT has a limitation in diagnosing acute coronary syndromes, the fat attenuation index (FAI) which is a novel imaging biomarker measured by clinical coronary CT angiography (CCTA), has been known to noninvasively detect coronary artery inflammation. We investigated the postmortem diagnostic usefulness of perivascular FAI measured by CCTA in a 61-year-old male who died suddenly after chest pain.

Evaluation of the measurement accuracy and uncertainty of a solid-state detector under diagnostic x-ray beam conditions.

Objective: An accurate measurement of x-ray beams is expected to reduce the uncertainties associated with estimating radiation risk to patients in clinical settings. To perform assessment tasks based on the readings of a solid-state detector (SSD) using semiconductor technology, the characteristics of the detector should be elucidated. In this study, we evaluated the measurement accuracy of a new SSD under diagnostic x-ray beam conditions in terms of air kerma, tube voltage, and half-value layer (HVL).