Publications by authors named "H Saiga"
PLAAT5 as an N-acyltransferase responsible for the generation of anti-inflammatory N-acylethanolamines in testis.
Biochim Biophys Acta Mol Cell Biol Lipids
November 2024
Article Synopsis
- N-Acylethanolamines (NAEs) are lipid mediators important for reducing inflammation and suppressing appetite, with palmitoylethanolamide (PEA) and arachidonoylethanolamide (AEA) interacting with specific receptors.
- The enzyme PLAAT5 is highlighted as crucial for producing NAEs in testes, as research using PLAAT5-deficient mice revealed a significant drop in NAE levels and their associated anti-inflammatory effects.
- Inflammation in testicular tissue was exacerbated in PLAAT5-deficient mice but could be mitigated by PEA and AEA, indicating that these compounds could provide protective roles through their receptor pathways.
Background: Esophagectomy with lymphadenectomy is the primary treatment for esophageal squamous cell carcinoma (ESCC). However, intensive dissection of lymph nodes (LNs) along the recurrent laryngeal nerve (RLN) is associated with RLN palsy and pulmonary complications leading to poor survival. Therefore, this study aimed identify the risk factors for LNs metastasis along the RLN in patients with ESCC.
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- After esophagectomy, patients often experience anastomotic strictures that complicate food passage and increase the risk of aspiration pneumonia, potentially affecting quality of life and nutrition.
- A study of 188 patients who underwent minimally invasive esophagectomy identified that 23% developed strictures, with a significantly higher occurrence among those who had neoadjuvant chemotherapy.
- Early intervention—specifically within 69 days post-surgery—was found to be a crucial risk factor for requiring more than five balloon dilatations to treat strictures, indicating a need for careful treatment planning.
Article Synopsis
- * Key findings revealed that different cut-off values for resected LN counts varied by anatomical areas (upper, middle, lower mediastinal, and abdominal) and patient types (upper/middle thoracic and lower thoracic ESCC).
- * Overall survival for patients with upper/middle thoracic ESCC was significantly influenced by resected LNs from the upper mediastinal area, while for lower thoracic cases, factors like tumor invasion depth and pulmonary complications were more critical
There is a liver damage in a serious side effect of regorafenib. Case 1 was a 54-year-old woman, and she had an operation of rectal cancer and metastasized to multiple organs afterwards and started regorafenib as third-line. Erythema exudativum multiform developed on the 8th day after a start and regorafenib was canceled once and reduced on the 21st day when a skin symptom was relieved and restarted.
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