Restoring hematopoietic stem and progenitor cell function in mice by delivery of RNA lipid nanoparticles.

Fanconi anemia (FA) is a congenital multisystem disorder characterized by early-onset bone marrow failure (BMF) and cancer susceptibility. While gene addition and repair therapies are being considered as treatment options, depleted hematopoietic stem cell (HSC) pools, poor HSC mobilization, compromised survival during transduction, and increased sensitivity to conventional conditioning strategies limit eligibility for FA patients to receive gene therapies. As an alternative approach, we explored protein replacement by mRNA delivery via lipid nanoparticles (LNPs).

The effect of therapeutic education program on hypertensive Tunisian patients' knowledge: a randomized controlled trial.

Background: Hypertension is a prevalent non-communicable disease and unequivocally one of the most serious health threats of the twenty-first century. The prevention of both immediate and long-term consequences depends on ongoing therapeutic education.

Aims: To assess Tunisian hypertensive patients' knowledge of hypertension and then evaluate the impact of an educational program on knowledge among this population.

Bedouin Adolescents during the Iron Swords War: What Strategies Help Them to Cope Successfully with the Stressful Situation?

This study examined the emotional reactions and coping resources of Bedouin teenagers (ages 12-18) following the events of 7 October 2023 and the subsequent Iron Swords War between Israel and Hamas forces in Gaza. This study focused on the relationships between subjective exposure, personal sense of coherence, community resilience, and the use of different coping strategies, on the one hand, and anxiety, anger, and psychological distress, on the other. During 2024, 762 participants completed the study questionnaire, which addressed the different study variables.