Similar antagonistic effects of Ca N-acetylhomotaurinate on depression of motor activity and lethality induced by acetaldehyde or ethanol.

Among several taurine derivatives, Ca N-acetylhomotaurinate (Ca AOTA) appears to be the most active anti-acetaldehyde and anti-alcohol agent. Studies of the antagonism of the hypomotility induced by high intravenous doses of acetaldehyde or ethanol in mice and of the lethality of high intragastric doses of acetaldehyde in rats show its superiority which appears logical after systematic studies of these derivatives and their components. The reinforcing action of the nervous activity due to N-acetylation of these sulfonic aminoacids differs according to the target.

Protective action of sulfur compounds against aldehyde toxicants of cigarette smoke.

Acetaldehyde, acrolein, and formaldehyde are important toxicants of cigarette smoke. Since acetaldehyde is a toxicant common to both heavy alcohol drinking and heavy cigarette smoking, protection studies were undertaken in rats first against acetaldehyde lethality and later against acrolein and formaldehyde lethality. This paper summarizes findings from previously published studies.

Protective action of ascorbic acid and sulfur compounds against acetaldehyde toxicity: implications in alcoholism and smoking.

Acetaldehyde is a toxic substance common to heavy drinking of alcohol and heavy smoking of cigarettes. It has been implicated thereby in diseases of the cardiovascular, respiratory, and central nervous systems. Protection against acetaldehyde toxicity (i.