Publications by authors named "H SCHREIBER"
Paediatric medulloblastomas with chromothripsis are characterised by high genomic instability and are among the tumours with the worst prognosis. However, the molecular makeup and the determinants of the aggressiveness of chromothriptic medulloblastoma are not well understood. Here, we apply spatial transcriptomics to profile a cohort of 13 chromothriptic and non-chromothriptic medulloblastomas from the same molecular subgroup.
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- The study investigates the effectiveness of enoxaparin, a medication for preventing blood clots, in critically ill children, focusing on differences in response based on age, particularly between older children and infants.
- It consists of two simultaneous clinical trials: one for older children aged 1-17 years, and another for infants under 1 year, with specific dosing protocols for each group.
- The trials are set in multiple pediatric intensive care units across the U.S., using methods like randomization, ultrasonography, and blood analysis to assess outcomes and monitor safety.
Article Synopsis
- The study aimed to determine if eating during labor affects outcomes by comparing food consumption to clear fluids in laboring patients.
- 129 healthy patients were randomized into two groups: one allowed to eat and the other restricted to clear fluids, with various maternal and neonatal outcomes measured.
- Results showed no significant differences in complications, labor progression, or outcomes between the two groups, leading to the conclusion that eating during labor is generally safe but should be approached cautiously based on individual patient risk factors.
Low-abundance members of microbial communities are difficult to study in their native habitats, including Escherichia coli, a minor but common inhabitant of the gastrointestinal tract, and key opportunistic pathogen of the urinary tract. While multi-omic analyses have detailed interactions between uropathogenic Escherichia coli (UPEC) and the bladder mediating urinary tract infection (UTI), little is known about UPEC in its pre-infection reservoir, the gastrointestinal tract, partly due to its low relative abundance (<1%). To sensitively explore the genomes and transcriptomes of diverse gut E.
View Article and Find Full Text PDFBackground: Best supportive care (BSC) measures are an essential component for the management of primary progressive multiple sclerosis (PPMS).
Objectives: RETRO PPMS (ML39631) is the first study to systematically analyze the therapeutic journey and standard of BSC of patients with PPMS in Germany.
Design: This multicenter, non-interventional study retrospectively analyzed patient charts.