Radiocardiographic assessment of dobutamine and isosorbide dinitrate therapy in patients with mitral stenosis and pulmonary congestion.

Simultaneous hemodynamic and radiocardiographic measurements were performed on 10 patients with mitral stenosis and pulmonary congestion for evaluating the acute effects of dobutamine (DB, 5 micrograms/kg/min), isosorbide dinitrate (ISD, 10 mg sublingually) or a combination of the two. DB alone produced a significant increase of the cardiac index (CI) from 2.9 +/- 0.

2,3-Bisphosphoglycerate in developing rabbit erythroid cells.

Rabbits were made anemic to different extents by phenylhydrazine injections so as to vary the developmental stages of the erythroid cells in their peripheral blood and bone marrow. It was found that the more severe the anemia, the lower the concentration of glycerate-2,3-P2 in the bone marrow cells and in the circulating erythroid cells. The glycerate-2,3-P2 level was shown to rise during erythroid differentiation in a linear relationship to the hemoglobin level, corresponding to the equation Y = 0.

Role of endocrine factors in chronic congestive heart failure, with emphasis on catecholamines.

Changes in endocrine activity in response to tilting of the body were studied in 16 in-patients with various degrees of chronic congestive heart failure and one healthy subject. Norepinephrine and epinephrine excretion, plasma renin activity and plasma cortisol concentration were determined first in recumbency and then during 45 degree head-up tilting. The subjects were divided into three groups depending on the severity of heart failure.

Left atrial infarction with saddle embolism.

Left atrial and left ventricular infarction with various atrial arrhythmias, multiple systemic arterial thromboembolism, and a large mural thrombus over the left atrial infarction is reported. In ischemic heart disease, systemic arterial thromboembolism may develop due to atrial infarction which is often overlooked in antemortem as well as in postmortem examinations. When a clinical diagnosis of atrial infarction is made, the possibility of a Stokes-Adams syndrome, thromboembolism, and rupture of the atrium should also be investigated.

Paroxysmal atrial fibrillation with asystole and syncope: report of a case of sinus node dysfunction with hypokalemia and hypertension.

A patient is presented who developed syncope due to asystole following paroxysmal atrial fibrillation. Suppression of intrinsic cardiac pacemakers during tachycardia is postulated as the mechanism for asystole. This patient might have sinus node dysfunction.