Publications by authors named "H S Wiley"
Predictive models of signaling pathways have proven to be difficult to develop. Traditional approaches to developing mechanistic models rely on collecting experimental data and fitting a single model to that data. This approach works for simple systems but has proven unreliable for complex systems such as biological signaling networks.
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- The study evaluates the effectiveness of the oral drug belzutifan in treating retinal hemangioblastomas associated with von Hippel-Lindau disease during the LITESPARK-004 trial.
- The analysis included 61 participants, with 12 having evaluable retinal lesions; all of the assessed eyes showed improvement after treatment, leading to a 100% response rate.
- By the end of the follow-up, no new disease progression was reported, and significant reductions in the size of hemangioblastomas were observed in a subgroup of patients, indicating the drug's potential efficacy.
Biochemical reaction networks perform a variety of signal processing functions, one of which is computing the integrals of signal values. This is often used in integral feedback control, where it enables a system's output to respond to changing inputs, but to then return exactly back to some pre-determined setpoint value afterward. To gain a deeper understanding of how biochemical networks are able to both integrate signals and perform integral feedback control, we investigated these abilities for several simple reaction networks.
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- The study focuses on the effectiveness and safety of oral minocycline for treating geographic atrophy (GA) in age-related macular degeneration (AMD), addressing the limitations of existing therapies.
- Conducted over 45 months, the trial involved 37 participants who were monitored during a 9-month run-in phase followed by 3 years of treatment with oral minocycline.
- Results showed no significant difference in the rate of GA enlargement between the treatment phase and the run-in phase, suggesting that minocycline may not be effective in slowing GA progression.
Article Synopsis
- Design patterns are general solutions to common problems, originally created by architects and computer scientists for better design abstraction.
- This text applies design patterns to cell biology, categorizing them into creational, structural, and behavioral patterns related to cell reaction networks.
- The approach offers new insights into various biological systems, including the E. coli central metabolic network and yeast pheromone response signaling.