Publications by authors named "H S Vora"
Background: The terminal ileum is typically examined during colonoscopies, especially in patients with inflammatory bowel disease (IBD) and diarrhea. The yield from performing biopsies of endoscopically normal appearing terminal ileum is less clear, and may be associated with greater costs, healthcare utilization and risk. We aimed to determine whether the biopsy results from endoscopically normal terminal ileum affect clinical management.
View Article and Find Full Text PDFPrediabetes and diabetes in India: An HbA1c based epidemiology study.
Diabetes Res Clin Pract
November 2024
Article Synopsis
- The study examines the growing issue of Type 2 diabetes and prediabetes in India by analyzing lab data from nearly 2 million adults in 2023, highlighting significant state-by-state variations in prevalence.
- Results indicate that 22.25% of adults have prediabetes and 27.18% have diabetes, with the highest rates in Odisha and the lowest in Jammu & Kashmir, and a marked increase in diabetes prevalence among males and working-age individuals.
- The findings underline the necessity for regular health screenings and suggest that dietary factors, particularly grain consumption, play a crucial role in managing and understanding these conditions.
PTPN2 (protein tyrosine phosphatase non-receptor type 2, or TC-PTP) and PTPN1 are attractive immuno-oncology targets, with the deletion of Ptpn1 and Ptpn2 improving response to immunotherapy in disease models. Targeted protein degradation has emerged as a promising approach to drug challenging targets including phosphatases. We developed potent PTPN2/N1 dual heterobifunctional degraders (Cmpd-1 and Cmpd-2) which facilitate efficient complex assembly with E3 ubiquitin ligase CRL4, and mediate potent PTPN2/N1 degradation in cells and mice.
View Article and Find Full Text PDFBackground: In response to the COVID-19 pandemic, the Pandemic Breast Cancer Consortium (PBCC) published recommendations for triage of breast cancer patients. The recommendations included neoadjuvant treatment of early-stage breast cancer patients experiencing delays in surgery. This study evaluated national patterns of neoadjuvant treatment according to triage guidelines.
View Article and Find Full Text PDFFragmentation of care in breast cancer: greater than the sum of its parts.
Breast Cancer Res Treat
December 2024
Introduction: Fragmentation of care (FC, the receipt of care at > 1 institution) has been shown to negatively impact cancer outcomes. Given the multimodal nature of breast cancer treatment, we sought to identify factors associated with FC and its effects on survival of breast cancer patients.
Methods: A retrospective analysis was performed of surgically treated, stage I-III breast cancer patients in the 2004-2020 National Cancer Database, excluding neoadjuvant therapy recipients.