Publications by authors named "H S Suzen"
Article Synopsis
- - This study investigated the link between exposure to persistent organic pollutants (POPs) and the development of kidney tumors, analyzing samples from patients who had kidney surgery and a control group for comparison.
- - Researchers measured POP concentrations in blood and various kidney-associated tissues, and assessed urinary markers indicating oxidative stress and potential DNA damage.
- - Findings suggested a connection between high levels of certain POPs and an increased risk of kidney cancer, with specific genetic factors, like the GSTT1 null polymorphism, potentially influencing this risk.
We investigated possible associations between the internal concentrations of POPs and correlations between blood and tumor tissue concentrations in patients who underwent surgery for breast cancer and breast reduction as controls. Genetic variations in CYP1A1, GSTP1, GSTM1, and GSTT1 and hOGG1 were evaluated to determine whether they represent risk factors for breast cancer. Certain POPs have been found to be associated with breast cancer development.
View Article and Find Full Text PDFSomatic DNA damage and causative factors (occupational exposures, foods, habits, etc.) are thought to contribute to the pathogenesis of atherosclerosis, although knowledge about their role in coronary artery disease (CAD) is still insufficient. This study aimed to determine the effects of lymphocyte-DNA damage and blood trace element concentrations on CAD.
View Article and Find Full Text PDFBackground: Despite its advantages over other antipsychotics, for treatment-resistant schizophrenia, clinical use of Clozapine (CLZ) is challenging by its narrow therapeutic index and potentially life-threatening dose-related adverse effects.
Research Design And Methods: As the potential role in CLZ metabolism is assigned to CYP1A2 enzyme and consequently Cytochrome P450 oxidoreductase (POR) their genetic variations might help to determine CLZ levels in schizophrenia patients. For this purpose, 112 schizophrenia patients receiving CLZ were included in the current study.