Correlation of repetitive behaviors in deer mice with striatal mRNA expression of endogenous opioids and mu, delta, kappa, and dopamine receptors.

Deer mice provide a valuable naturally occurring animal model for investigating pathophysiological mechanisms underlying repetitive behaviors. Prior investigations using this model have identified abnormalities in the cortico-basal ganglia circuitry, including alterations within the indirect pathway and levels of endogenous opioids in the frontal cortex. In this study, the behaviors of n = 7 mice were quantified, and their brains were sectioned.

High-quality draft genomes of ecologically and geographically diverse species.

is a genus of mushroom-forming fungi with ecological, ethnomycological, and clinical importance due to psilocybin production by most species. We present five genomes that enable deeper discovery and analysis of the psilocybin gene cluster and increase taxonomic resolution within : , nom. prov.

Caregivers and Coping: Well-Being, Depression, and Coping Strategies Among Caregivers of Young Adults With Developmental Disabilities.

This 10-year study followed 134 caregivers of young adults with autism and intellectual disabilities, examining the effects of caregivers' coping strategies, sociodemographic features, and young adult symptomatology on caregiver well-being and depression. Lower caregiver education and higher young adult externalizing behaviors predicted lower well-being and higher depression among caregivers. Caregivers who were Black or mixed-race experienced higher depression than White caregivers.

Integrating Biological Early Warning Systems with High-Resolution Online Chemical Monitoring in Wastewater Treatment Plants.

Detection of micropollutants (MPs) in wastewater effluents using traditional toxicity tests or chemical analysis with discrete samples is challenging due to concentration dynamics. This study evaluates a continuous monitoring approach for detecting MPs in wastewater effluents using a combination of biological early warning systems (BEWS). Three BEWS with , , and were operated in parallel in a full-scale municipal wastewater treatment plant.

Autism at 30: Conceptualizations for adult research and clinical practice.

Autism spectrum disorder is one of the most common neurodevelopmental conditions diagnosed in children. Most autism research, intervention, and policy focus exclusively on this condition in childhood, but autism often persists across the life course. This narrative review leverages data from 115 participants first diagnosed with autism between ages 2 and 3 years and subsequently followed for 3 decades ( = 30.