Publications by authors named "H S Richards"
Article Synopsis
- The study investigates how cancer cells influence the fitness of surrounding tumor microenvironment (TME) cells through a mechanism involving a long non-coding RNA called Tu-Stroma, which alters the expression of Flower isoforms, impacting their growth advantage.
- The expression of Flower Win isoforms in cancer cells enhances their dominance over TME cells that express Flower Lose isoforms, leading to reduced fitness in the TME.
- Targeting Flower proteins with a humanized monoclonal antibody in mice has shown promising results, significantly reducing cancer growth and metastasis while improving survival rates and protecting organs from potential lesions.
Article Synopsis
- Patients' beliefs about their kidney stone (KS) condition play a crucial role in their adjustment and adherence to self-management, with this study being the first to quantitatively analyze these beliefs.
- A survey of 112 KS patients revealed that a significant portion (31.2%) didn't know the cause of their condition, while those who did attributed it mainly to dietary choices, fluid intake, and medical risk factors.
- Findings also indicated that while patients felt fairly knowledgeable about KS, they expressed low personal control over their condition and high confidence in treatment effectiveness, emphasizing the need to enhance their sense of control in managing KS.
Feasibility and diagnostic accuracy of neonatal anthropometric measurements in identifying low birthweight and preterm infants in Africa: a systematic review and meta-analysis.
Fitsum Weldegebriel Belay Rekiku Fikre Akalewold Alemayehu Andrew Clarke Sarah Williams Hannah Richards
BMJ Paediatr Open
October 2024
Article Synopsis
- Complications from prematurity are the main cause of infant deaths globally, especially among low birth weight (LBW) babies, highlighting the need for early identification.
- This study reviews the effectiveness of using simple anthropometric measurements like foot length, mid-upper arm circumference (MUAC), and circumferences of the head and chest to detect LBW and preterm infants in Africa.
- The findings indicate that foot length and MUAC are reliable indicators for identifying LBW and preterm infants, with high accuracy rates, and can be measured easily without risking infant safety.
Objective: Our goal was to assess the efficacy and safety of intravenous (IV) secukinumab for the treatment of adults with active axial spondyloarthritis (axSpA) in INVIGORATE-1.
Methods: INVIGORATE-1 (NCT04156620) was a randomized, double-blind, parallel-group, phase 3 trial in patients with active axSpA (either radiographic or nonradiographic). Patients were randomized one to one to receive IV secukinumab (6 mg/kg at baseline followed by 3 mg/kg every four weeks) or IV placebo for 16 weeks.