Publications by authors named "H S Lindsey"
In 2018, the Veterans Health Administration (VHA) established the original 19 Headache Centers of Excellence (HCoE) program, and an evaluation center. This study utilized a Veteran engagement group method to elicit input from Veteran patients living with chronic headache on daily needs, social determinants of health, and preferences and suggestions for headache programs, services, and research priorities. Four engagement groups were conducted between July 13 and August 22 of 2022 with Veterans who experience headache and received care at a VHA HCoE.
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- A study found that changes in the brain entorhinal cortex (EC) and specific blood lipids are linked to Alzheimer's disease (AD) in individuals with the apolipoprotein E ε4 genetic variant.
- Analysis of brain imaging and lipid profiles revealed that ε4 carriers with mild traumatic brain injury (mTBI) had thicker left ECs, but repeated mTBIs reduced right EC thickness.
- The research highlights the need for further investigation into the relationship between ε4, mTBI, and specific blood lipid ratios as potential biomarkers for early detection of AD in affected individuals.
Importance: Blast-related mild traumatic brain injuries (TBIs), the "signature injury" of post-9/11 conflicts, are associated with clinically relevant, long-term cognitive, psychological, and behavioral dysfunction and disability; however, the underlying neural mechanisms remain unclear.
Objective: To investigate associations between a history of remote blast-related mild TBI and regional brain volume in a sample of US veterans and active duty service members.
Design, Setting, And Participants: Prospective cohort study of US veterans and active duty service members from the Long-Term Impact of Military-Relevant Brain Injury Consortium-Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC), which enrolled more than 1500 participants at 5 sites used in this analysis between 2014 and 2023.
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- Neuroscience researchers are leveraging Big Data to improve the reliability of findings by increasing sample sizes and addressing replication issues.
- A study analyzed data from 53 studies with over 10,500 participants to connect scores from various auditory verbal learning tasks (AVLTs) while controlling for site-related effects.
- The research successfully reduced score variance by 37% and developed an online tool to help researchers and clinicians convert memory scores across different tests, highlighting the benefit of global data harmonization in behavioral sciences.
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- Patients with active cancer or metastatic cancer are at a higher risk for acute cholecystitis, leading to increased complications and mortality when they receive surgical treatment.
- A study analyzed the treatment outcomes of 8,673 patients with acute cholecystitis, finding that those with cancer had a significantly higher 30-day mortality rate and higher chances of complications such as infectious issues.
- The findings suggest that cancer patients are often managed nonoperatively more than non-cancer patients, highlighting the need for tailored treatment approaches due to their distinct risk factors.