Publications by authors named "H S Kirshner"
Article Synopsis
- The study investigates how the immune system of young macaques can produce antibodies that neutralize various strains of HIV-1, showing a higher success rate in infants compared to adults.
- Over a 24-month period, 64% of young macaques developed these antibodies, linked to a healthier immune profile with reduced immunosuppressive factors.
- The findings suggest that understanding pediatric immune responses to SHIV may help in creating vaccines to protect infants and children from HIV-1 before they are exposed to the virus.
A critical roadblock to HIV vaccine development is the inability to induce B cell lineages of broadly neutralizing antibodies (bnAbs) in humans. In people living with HIV-1, bnAbs take years to develop. The HVTN 133 clinical trial studied a peptide/liposome immunogen targeting B cell lineages of HIV-1 envelope (Env) membrane-proximal external region (MPER) bnAbs (NCT03934541).
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