Publications by authors named "H S Hira"

Article Synopsis
  • Lindane (LDN) is a herbicide that harms the liver, leading to changes in important cellular pathways and increased damage markers in rats.
  • In a study with rats, those treated with LDN showed increased harmful compounds and impaired liver function markers compared to control groups.
  • Administering catechin (CTN) alongside LDN helped protect the liver by enhancing antioxidant defenses and reducing cell damage, highlighting CTN’s potential therapeutic effects.
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Posterior reversible encephalopathy syndrome (PRES) is a pathology seen not only in precelampsia with severe symptoms and eclampsia but in a varicty of diseases/ conditions. With the availability of neuroimaging, it is possible to know the exact underlying Central nervous system (CNS) pathology in preeclampsia with severe symptoms and eclampsia and thus therapy can be targeted. Preeclampsia with severe symptoms and eclampsia remains to be an important cause of maternal morbidity and mortality in both the developing and developed world.

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Introduction Gastrointestinal parasitic infections are one of the global health concerns in developing countries like Bangladesh. Among them, spp. plays an essential role in causing diarrhea, malnutrition, and poor cognitive function, especially in children.

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Gretchen Hagen 3 (GH3) amido synthetases conjugate amino acids to a carboxyl group of small molecules including hormones auxin, jasmonate, and salicylic acid. The Arabidopsis genome harbors 19 GH3 genes, whose exact roles in plant development have been difficult to define because of genetic redundancy among the GH3 genes. Here we use CRISPR/Cas9 gene editing technology to delete the Arabidopsis group II GH3 genes, which are able to conjugate indole-3-acetic acid (IAA) to amino acids.

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Article Synopsis
  • This study reveals the main pathway for inactivating the plant hormone auxin, specifically indole-3-acetic acid (IAA), through the GH3-ILR1-DAO pathway.
  • The process begins with GH3 enzymes converting IAA into storage forms (IAA-aspartate and IAA-glutamate), which can be reverted back to active IAA by ILR1/ILL enzymes.
  • Additionally, DAO1 irreversibly oxidizes these storage forms into inactive compounds, highlighting the significance of this pathway for maintaining auxin levels during plant development.
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