Publications by authors named "H S Friedman"
Background: Establishing surrogate endpoints for overall survival (OS) may expedite assessment of new therapies in esophageal cancer (EC) and gastroesophageal junction cancer (GEJC). This study aimed to evaluate disease-free survival (DFS) as a surrogate endpoint for OS.
Methods: Patients from the Surveillance, Epidemiology, and End Results (SEER)-Medicare database aged ≥66 years with resection after primary diagnosis of stage 2 or 3 EC/GEJC between 2009 and 2017 were analyzed (N = 925; median follow-up 26.
Article Synopsis
- The study focused on social needs of Veterans living in rural areas, revealing that over 80% reported at least one social need, with social disconnection being the most prevalent, especially in the Southeast site.
- Analysis showed significant links between various social needs, especially financial and activities of daily living, and poorer physical and mental health outcomes.
- The findings emphasize the importance of health systems addressing social determinants of health and suggest that interventions should be customized to fit the unique needs of different Veteran populations.
Article Synopsis
- The hypothalamic-pituitary-adrenal (HPA) axis is key in stress responses, with Crh from the hypothalamus triggering cortisol release from the adrenal gland, influencing anxiety behaviors in mice.
- A study showed that deleting Crh in the hypothalamus reduced anxiety in mice, but this effect was not observed in cases of primary adrenal insufficiency or after treatment with dexamethasone.
- Despite different genetic backgrounds and DEX treatments, all mouse groups demonstrated similar anxiety levels, suggesting that changes in Crh expression might not significantly impact anxiety in conditions like adrenal insufficiency or glucocorticoid therapy.