Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice.

NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and the coordinated activity between central brain and peripheral liver clock proteins postulated to be instrumental for linking behaviour and metabolism. We investigated a conditional liver-specific knockout mouse model (Npas2-/- or cKO) to explore its function in activity, circadian rhythms and cognition (novel object recognition-NOR). Circadian rhythms showed no genotype differences.

A review of microcredentials in health professions continuing professional development.

Microcredentials are an emergent tool to support knowledge and skill development. Despite their growing popularity in medical education - and higher education more broadly - it is unclear how these strategies have been utilized to support continuing professional development in the health professions. A rapid systematic review was conducted to explore the current relevant literature due to the timely and evolving nature of microcredentials.

Improving recruitment and retention of people with Parkinson's disease to clinical studies: A scoping review.

Background: Timely recruitment and effective retention of participants are challenging for clinical Parkinson's disease (PD) research studies. Not achieving this can affect delivery costs and bias results.

Objective: To identify successful recruitment and retention methodologies for clinical research studies in PD.

Cross-Sectional Validation of an Automated Lesion Segmentation Software in Multiple Sclerosis: Comparison with Radiologist Assessments.

Background And Purpose: Magnetic Resonance Imaging is widely used to assess disease burden in multiple sclerosis (MS). This study aimed to evaluate the effectiveness of a commercially available k-nearest neighbors (k-NN) software in quantifying white matter lesion (WML) burden in MS. We compared the software's WML quantification to expert radiologists' assessments.