NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and the coordinated activity between central brain and peripheral liver clock proteins postulated to be instrumental for linking behaviour and metabolism. We investigated a conditional liver-specific knockout mouse model (Npas2-/- or cKO) to explore its function in activity, circadian rhythms and cognition (novel object recognition-NOR). Circadian rhythms showed no genotype differences.
View Article and Find Full Text PDFMicrocredentials are an emergent tool to support knowledge and skill development. Despite their growing popularity in medical education - and higher education more broadly - it is unclear how these strategies have been utilized to support continuing professional development in the health professions. A rapid systematic review was conducted to explore the current relevant literature due to the timely and evolving nature of microcredentials.
View Article and Find Full Text PDFBackground: Timely recruitment and effective retention of participants are challenging for clinical Parkinson's disease (PD) research studies. Not achieving this can affect delivery costs and bias results.
Objective: To identify successful recruitment and retention methodologies for clinical research studies in PD.
Am J Physiol Heart Circ Physiol
March 2025
Background And Purpose: Magnetic Resonance Imaging is widely used to assess disease burden in multiple sclerosis (MS). This study aimed to evaluate the effectiveness of a commercially available k-nearest neighbors (k-NN) software in quantifying white matter lesion (WML) burden in MS. We compared the software's WML quantification to expert radiologists' assessments.
View Article and Find Full Text PDF