Myotubularin-related protein-6 silencing protects mice from Leishmania donovani infection.

The protozoan parasite Leishmania donovani resides within mammalian macrophages and alters its antigen-presenting functions to negatively regulate host-protective T cell responses. This negative regulation of human T cell responses in vitro is attributed to myotubularin-related protein-6 (MTMR6), an ion channel-associated phosphatase. As mouse and human MTMR6 share homology, we studied whether MTMR6 silencing by lentivirally expressed MTMR6shRNA (Lv-MTMR6shRNA) reduced Leishmania growth in macrophages and whether MTMR6 silencing in Leishmania-susceptible BALB/c mice reduced the infection and reinstated host-protective T cell functions.

Biotechnological advances in biomass pretreatment for bio-renewable production through nanotechnological intervention.

Globally, the fossil fuel reserves are depleting rapidly and the escalating fuel prices as well as plethora of the pollutants released from the emission of burning fossil fuels cause global warming that massively disturb the ecological balance. Moreover, the unnecessary utilization of non-renewable energy sources is a genuine hazard to nature and economic stability, which demands an alternative renewable source of energy. The lignocellulosic biomass is the pillar of renewable sources of energy.

Interdependencies between Toll-like receptors in Leishmania infection.

Multiple pathogen-associated molecular patterns (PAMPs) on a pathogen's surface imply their simultaneous recognition by the host cell membrane-located multiple PAMP-specific Toll-like receptors (TLRs). The TLRs on endosomes recognize internalized pathogen-derived nucleic acids and trigger anti-pathogen immune responses aimed at eliminating the intracellular pathogen. Whether the TLRs influence each other's expression and effector responses-termed TLR interdependency-remains unknown.

Should I stay or should I go? Pigeons' (Columba livia) performance of a foraging task has implications for optimal foraging theory and serial pattern learning.

Optimal foraging theory suggests that animals have evolved to maximize their net rate of energy intake; all things being equal, they should leave a current depleting patch when an alternative patch would provide either more or sooner food. In nature, however, typically all things are not equal. For example, uncertainty about the value of alternative patches, time to travel to those patches, and potential dangers incurred in changing patches may delay leaving the depleting patch, when it would otherwise be optimal to do so.

In situ photodecyanation of steel industry wastewater in a pilot scale.

The photodegradation of cyanide from steel industry wastewater was explored in pilot plant scale using hydrogen peroxide (HO) under UV irradiation. However, it was interesting to notice that only HO or only UV was inefficient to degrade the cyanide from industrial wastewater. There was a synergy between HO and UV radiation for the degradation of cyanide.