Publications by authors named "H Rossmann"
Congenital defects of the erythrocyte membrane are common in northern Europe and all over the world. The resulting diseases, for example, hereditary spherocytosis (HS), are often underdiagnosed, partly due to their sometimes mild and asymptomatic courses. In addition to a broad clinical spectrum, this is also due to the occasionally complex diagnostics that are not available to every patient.
View Article and Find Full Text PDFBackground: ADAMTS-13 adopts an open conformation in patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP) in acute phase while being closed in healthy donors. We reported that a substantial number of patients with iTTP in remission with restored ADAMTS-13 activity (>50%) still had an open ADAMTS-13 conformation, although a closed conformation is expected given the extent of remission.
Objectives: To investigate whether open ADAMTS-13, represented by a conformation index >0.
Article Synopsis
- Overweight and obesity are significant health issues linked to various complications and high treatment costs, highlighting the need for health policy attention.
- The Gutenberg Health Study examined individuals aged 35-74 in Mainz and found that many were overweight or obese, with higher body mass index (BMI) correlating to serious health problems like diabetes and heart disease.
- The study revealed a notable increase in obesity rates over a decade, indicating an ongoing trend of rising BMI among men and women, alongside increased medication use for obesity-related health issues.
Article Synopsis
- * A specific genetic mutation (R253*) was found in two siblings experiencing severe neurological and tumor-related health issues, which was associated with significant cellular abnormalities and inefficient protein function.
- * Another mutation (R227*) identified in a different patient is likely tied to complete loss of p31comet function, further indicating that mutations in this gene are linked to risks for aneuploidy and cancer development.
Background: COVID-19 is a worldwide pandemic caused by the highly infective SARS-CoV-2. There is a need for biomarkers not only for overall prognosis but also for predicting the response to treatments and thus for improvements in the clinical management of patients with COVID-19. Circulating cell-free DNA (cfDNA) has emerged as a promising biomarker in the assessment of various pathological conditions.
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