Publications by authors named "H Robert Silverstein"
Background And Objectives: Palliative care (PC) is a specialty medical service that aims to address the bio-psycho-social-spiritual needs of patients with serious illnesses and their care partners. Despite the value of PC, its expansion in Sub-Saharan Africa has been uneven and particularly underdeveloped in Senegal due to variability in access to training resources and funding. This study sought to understand the current landscape of PC services in Senegal and the barriers and opportunities in its growth.
View Article and Find Full Text PDFSmall-molecule antivirals that prevent the replication of the SARS-CoV-2 virus by blocking the enzymatic activity of its main protease (Mpro) are and will be a tenet of pandemic preparedness. However, the peptidic nature of such compounds often precludes the design of compounds within favorable physical property ranges, limiting cellular activity. Here we describe the discovery of peptide aldehyde Mpro inhibitors with potent enzymatic and cellular antiviral activity.
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- Hyperacusis is a condition where people experience extreme sensitivity to everyday sounds, and a surgical procedure using temporalis fascia was developed for patients who don't respond to conservative treatments.
- A study involved 73 adults who underwent this surgery, categorized into two groups based on their preoperative Loudness Discomfort Levels (LDLs), with significant improvements noted post-surgery.
- The results showed that patients with higher LDLs (>70 dB) had a greater improvement in sound tolerance and quality of life, with 80.8% of them recommending the surgery, while those in the lower LDL group also improved but to a lesser extent.
An 8-week educational intervention co-taught by medical students and faculty was designed to foster communication between clinical researchers and populations of interest to ultimately increase participation in clinical research by older adults, including underrepresented groups. Weekly topics focused on age-related changes and health conditions, socio-contextual factors impacting aging populations, and wellness strategies. To evaluate the successes and weaknesses of an educational intervention aimed at increasing the participation of older adults in clinical research.
View Article and Find Full Text PDFBackground: Since March 2020, the coronavirus disease 2019 (COVID-19) pandemic has been a major shock to health systems across the world. We examined national usage patterns for selected basic, essential health services, before and during the COVID-19 pandemic in Uganda and Bangladesh, to determine whether COVID-19 affected reporting of service utilization and the use of health services in each country.
Methods: We used routine health information system data since January 2017 to analyze reporting and service utilization patterns for a variety of health services.