[Current hypotheses on the development of chronic otitis media with effusion in childhood].

Chronic otitis media with effusion (COME) has a major impact on a child's physical and social development. Socioeconomic risk factors as well as new insights gained with modern laboratory technology and large demographic studies of COME in Central Europe are discussed. In total, 428 articles from the past 8 years on PubMed were reviewed as well as current guidelines of German- and English-speaking countries on COME in children.

Identification of neutrophils and eosinophils in upper airway mucosa with immunofluorescence multiplex image cytometry.

Characterization of inflammation in chronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP) is an ongoing research process. To overcome limitations of current cytologic techniques, we investigated whether immunofluorescence multiplex image cytometry could quantify intact neutrophils, eosinophils, and other immune cells in solid upper airway mucosa. We used a four-channel immunofluorescence-microscopy technique for the simultaneous detection of the leukocyte marker CD45, the neutrophil marker myeloperoxidase, two eosinophil markers, i.

CT comparison of the nasal airway anterior and posterior to the piriform aperture in patients with and without nasal obstruction.

Background: Nasal airway stenosis may lie anterior and/or posterior to the piriform aperture. We intended to compare the nasal airway anterior and posterior to the piriform aperture in patients with and without nasal obstruction.

Methods: Segmented computed tomography cross-sectional areas of the nasal airway anterior (CT-CSA) and posterior to the piriform aperture (at the level of the head of the inferior turbinate; CT-CSA) were compared between patients with nasal obstruction (cases) and trauma controls.