Trans oral endoscopic thyroidectomy (TOETVA): First French experience in 90 patients.

Objective: Thyroidectomy techniques using extracervical approaches have grown in popularity for about 20 years and their feasibility has now been demonstrated. We wanted to evaluate one of these new approaches: the anterior vestibular endoscopic approach (TOETVA). The aim of this study was to evaluate the results of an initial series patients who underwent an anterior trans-vestibular endoscopic oral thyroidectomy.

FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer.

Aim: To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal cancer.

Methods: This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3 (day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m, irinotecan 90 mg/m, 5-fluorouracil infusion 2400 mg/m per 46 h; day 3: irinotecan 90 mg/m) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate (ORR).

Therapeutic strategy in unresectable metastatic colorectal cancer: an updated review.

Systemic therapy is the standard care for patients with unresectable advanced colorectal cancer (CRC), but salvage surgery of metastatic disease should be considered in the case of adequate tumor shrinkage. Several drugs and combinations are now available for use in treating patients with advanced CRC, but the optimal sequence of therapy remains unknown. Moreover, the administration of antitumor therapy can be modulated by periods of maintenance or treatment breaks rather than delivered as full therapy until disease progression or unacceptable toxicity, followed by reintroduction of prior full therapy when required, before switching to other drugs.

Group mental health interventions in civilian populations in war-conflict areas: a Lebanese pilot study.

Purpose: Cognitive behavioral (CB) group therapy is an effective therapeutic intervention to treat war-related trauma. The aim of this pilot study was to describe the effects of conducting CB group therapy in a civilian population exposed to war in southern Lebanon.

Method: Participants presenting with psychiatric symptoms attended an 8-week CB group therapy intervention adapted to the Lebanese culture.