Publications by authors named "H Reynaert"
Co-existing regeneration mechanisms in severe alcohol-related steatohepatitis.
Transl Gastroenterol Hepatol
January 2025
Background: Keratin 7 positive (K7) cells are considered to be activated in case of impaired hepatocyte replication. Their exact role and their interaction with hepatocytes and macrophages also implicated in liver regeneration remain poorly characterized in humans. The aim of this study is to evaluate hepatocyte, K7 cells and macrophage populations in severe alcohol-related steatohepatitis (sASH) and to link them with liver injury and patients' outcomes.
View Article and Find Full Text PDFBackground: Various endoscopic treatment options are available for managing colonic diverticular bleeding (CDB). We conducted a systematic review and meta-analysis to assess the effectiveness of these endoscopic interventions in achieving hemostasis in patients with CDB, focusing on early rebleeding rate (ERR) within 30 days.
Methods: A systematic literature search of the PubMed and Cochrane Library databases was performed for articles published between January 2008 and December 2023.
Article Synopsis
- This research explores the activation of hepatic stellate cells (HSCs) across different types of chronic liver disease (CLD), finding that their activation follows similar mechanisms regardless of the injury type.
- A single-cell RNA-sequencing atlas was created to categorize HSCs into three profiles: quiescent, initiatory, and myofibroblasts, indicating consistent activation patterns in both mice and humans.
- The study highlights key transcription factors and novel ligands involved in HSC activation, paving the way for new insights and potential treatments for liver fibrosis.
A cholecystocolonic fistula (CCF) is a rare cause of chronic diarrhoea. It most often occurs in elderly women as a result of chronic inflammation due to gallstone disease or, rarely, malignancy. Curative treatment consists of cholecystectomy with excision of the fistula tract, but it is often overlooked preoperatively and thus entails a higher risk of postoperative complications.
View Article and Find Full Text PDFThe lack of adequate humanmodels that recapitulate the cellular composition and response of the human liver to injury hampers the development of anti-fibrotic drugs. The goal of this study was to develop a human spheroid culture model to study liver fibrosis by using induced pluripotent stem cell (iPSC)-derived liver cells. iPSCs were independently differentiated towards hepatoblasts (iHepatoblasts), hepatic stellate cells (iHSCs), endothelial cells (iECs) and macrophages (iMΦ), before assembly into free floating spheroids by culturing cells in 96-well U-bottom plates and orbital shaking for up to 21 days to allow further maturation.
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