Response and variation mechanisms of RDX crystals under strong magnetic loading.

To fully understand the variation in performance of cyclotrimethylenetrinitramine (RDX) crystals under strong magnetic field exposure, the strong magnetic loading of RDX was conducted in both stable and alternating magnetic fields. The morphological changes of RDX crystals exposed to magnetic fields were studied under a scanning electron microscope. Then, the lattice changes of RDX exposed to magnetic fields were analyzed through X-ray diffraction and Raman spectroscopy.

PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.

Introduction: Heart failure with preserved ejection fraction (HFpEF) is a complex condition characterized by metabolic dysfunction and myocardial lipotoxicity. The roles of PTEN-induced kinase 1 (PINK1) and peroxiredoxin-2 (Prdx2) in HFpEF pathogenesis remain unclear.

Objective: This study aimed to investigate the interaction between PINK1 and Prdx2 to mitigate cardiac diastolic dysfunction in HFpEF.

Organoids in skin wound healing.

Stem cells (SCs) can self-replicate and differentiate into multiple lineages. Organoids, 3D cultures derived from SCs, can replicate the spatial structure and physiological characteristics of organs . Skin organoids can effectively simulate the physiological structure and function of skin tissue, reliably restoring the natural skin ecology in various environments.

Inherent Ultrahigh Proton Conductivity of Two Highly Stable COOH-Functionalized Hafnium-Based Metal-Organic Frameworks.

Although there has been some recent interest in the proton conductivity (σ) of highly stable carboxyl metal-organic frameworks (MOFs) made of tetravalent metal ions, given their potential applications in fuel cells and electrochemical sensing, research on MOFs constructed by hafnium(IV) ions needs to be expanded significantly. Based on this, we used two common and easily prepared phenylpoly(carboxylic acid) ligands, 1,2,4-phenyltricarboxylic acid and 1,2,4,5-phenyltetracarboxylic acid, to react with hafnium tetrachloride, respectively, creating two porous hafnium(IV)-based MOFs, () and UiO-66-(COOH)-Hf (), with the same structure as UiO-66-Hf but with different numbers of free carboxylic groups. A series of stability assays revealed that the two MOFs had excellent structural rigidity, including thermal and water stability.

Removal of mixed PhACs by combined UV/HO and biologically activated carbon process: Toxicity assessment, transformation products and microbial community.

This study examined the removal and toxicity reduction of mixed pharmaceutically active compounds (PhACs), including carbamazepine, erythromycin, gemfibrozil, and diclofenac, in the UV/HO tandem with biologically activated carbon (UV/HO-BAC) process and explored potential detoxification mechanisms. Results indicated that the combined process effectively removed the mixed PhACs, with the UV/HO segment being the primary contributor. As distinct from concentration removal, the effluent toxicity significantly increased after UV/HO treatment.