Publications by authors named "H Reed"
Small intestine neuroendocrine tumours (SI-NETs) are often diagnosed late with a UK median of 3 years and high misdiagnosis rates. Previous studies, largely based on patient surveys, offer little data on improving diagnosis. In 2017, the South Wales NET service underwent a nationally commissioned, systematic transformation, aiming to improve diagnosis through the development of a gastroenterology and surgical referral network, and education of these specialities.
View Article and Find Full Text PDFPurpose: This study aimed to evaluate the performance of different genetic screening approaches to identify women at high risk of breast cancer in the general population.
Methods: We retrospectively studied 25,591 women with available electronic health records and genetic data, participants in the Healthy Nevada Project.
Results: Family history of breast cancer was ascertained on or after the record of breast cancer for 78% of women with both, indicating that this risk assessment method is not being properly utilized for early screening.
This qualitative study explores the motivations, barriers, and facilitators underpinning the adoption of the Mindset Teams programme in primary schools across Scotland. Semi-structured interviews were conducted with 18 teachers across six Mindset Teams schools and 14 wider stakeholders working across local, regional, and national levels. Findings suggested underpinning factors across the socio-ecological model, with differential themes identified, including six supporting school motivations and ten spanning barriers and facilitators, across teacher and stakeholder data.
View Article and Find Full Text PDFArticle Synopsis
- Researchers observed that mice lacking a protein called CLEC2, which affects lymphatic function, develop lung issues similar to emphysema in COPD due to the formation of tertiary lymphoid organs (TLOs).
- Blocking the formation of these TLOs with an anti-CD20 antibody in these mice partially prevented the progression of emphysema and revealed that TLOs contributed to increased autoantibodies.
- The study also found that chronic exposure to cigarette smoke enlarged TLOs and was linked to more severe lung injury, and similar lymphatic changes were noted in lung tissues from COPD patients with emphysema, suggesting a connection between lymphatic dysfunction and autoimmune responses in lung disease.
Introduction: Previous studies have demonstrated deteriorations in young adult mental health during the COVID-19 pandemic, but evidence suggests heterogeneity in the mental health impacts of the pandemic. We sought to identify factors which may predict changes in psychological distress and wellbeing during the COVID-19 pandemic in UK young adults.
Methods: A total of 2607 young adults from the Millennium Cohort Study were included.