Fully Hyperbolic Neural Networks: A Novel Approach to Studying Aging Trajectories.

Characterizing age-related alterations in brain networks is crucial for understanding aging trajectories and identifying deviations indicative of neurodegenerative disorders, such as Alzheimer's disease. In this study, we developed a Fully Hyperbolic Neural Network (FHNN) to embed functional brain connectivity graphs derived from magnetoencephalography (MEG) data into low dimensions on a Lorentz model of hyperbolic space. Using this model, we computed hyperbolic embeddings of the MEG brain networks of 587 individuals from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) dataset.

SonquSim: Design and performance evaluation of an ECG and arrhythmia simulator for medical devices calibration.

Clinical engineers play a crucial role in ensuring the quality of electrocardiographs used in healthcare centers, utilizing standard metrology equipment to guarantee proper performance and patient safety. In this article, we present the design of a simulator for normal sinus rhythm and arrhythmic ECG signals. This device is tailored for use in resource-constrained settings, particularly in developing countries.

Quantification of subcellular RNA localization through direct detection of RNA oxidation.

Across cell types and organisms, thousands of RNAs display asymmetric subcellular distributions. Studying this process requires quantifying abundances of specific RNAs at precise subcellular locations. To analyze subcellular transcriptomes, multiple proximity-based techniques have been developed in which RNAs near a localized bait protein are specifically labeled, facilitating their biotinylation and purification.

The role of religiosity and spirituality in coping with sickle cell disease clinical severity.

Objectives: Religiosity and spirituality often play a role in managing chronic diseases. Sickle cell disease (SCD) is a genetic chronic disease associated with lifelong complications, but there is limited analysis of the potential impact of religiosity and spirituality on SCD. This study aims to analyze the association between constructs of religiosity and spirituality with health outcomes (disease severity, depression, and pain) in an SCD population ( = 275).

A Novel Vaccine for Bovine Diarrhea Complex Utilizing Recombinant Enterotoxigenic and Expressing Surface-Displayed Chimeric Antigens from Enterohemorrhagic O157:H7.

Background/objectives: (EHEC) O157:H7, a zoonotic pathogen primarily found in cattle, causes Hemolytic Uremic Syndrome (HUS) in humans, often through contaminated food. Its Type Three Secretion System (T3SS) facilitates gut colonization. In contrast, neonatal calf diarrhea (NCD) is mainly caused by pathogens like enterotoxigenic (ETEC), spp.