Publications by authors named "H Rakowski"
Article Synopsis
- Current methods to predict sudden cardiac death (SCD) in children with hypertrophic cardiomyopathy (HCM) are insufficient, although late gadolinium enhancement (LGE) in CMR imaging has shown a link to SCD in adults.
- This study aimed to assess the significance of LGE in HCM patients under 21 years, utilizing data from various international centers between 2015 and 2022.
- Results indicated that 32.9% of the 700 patients had LGE, and those with LGE were more likely to experience SCD or related events, emphasizing the potential role of LGE in clinical assessments for younger patients with HCM.
Article Synopsis
- The study investigates the relationship between clonal haematopoiesis (CH) and clinical outcomes in patients with hypertrophic cardiomyopathy (HCM), highlighting that CH may increase cardiovascular risks.
- Out of 799 HCM patients, 22.9% had CH, which correlated with more severe symptoms and greater fibrosis compared to those without CH.
- Patients with both HCM and CH faced significantly higher rates of major adverse cardiovascular events (MACE), especially those with specific gene mutations like DNMT3A, TET2, and ASXL1.
Objectives: There is limited data regarding the impact of exercise on phenotypic expression in hypertrophic cardiomyopathy (HCM). We aimed to investigate whether such an association exists in a cohort of genotype-positive HCM patients.
Methods: In this cross-sectional study of genotype-positive HCM families, we used structured questionnaires to obtain data regarding intensity and duration of exercise of participants starting at the age of 10, as well as data regarding exercise recommendations and their impact on quality of life (QOL).