Publications by authors named "H Rajak"

Globally, one of the most prevalent cancers is colorectal cancer (CRC). Chemotherapy and surgery are two common conventional CRC therapies that are frequently ineffective and have serious adverse effects. Thus, there is a need for complementary and different therapeutic approaches.

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Currently, cervical cancer (CC) is the fourth recorded widespread cancer among women globally. There are still many cases of metastatic or recurring disease discovered, despite the incidence and fatality rates declining due to screening identification and innovative treatment approaches. Palliative chemotherapy continues to be the standard of care for patients who are not contenders for curative therapies like surgery and radiotherapy.

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The multifaceted benefits of position it is not only as a promising agricultural commodity but also as a versatile resource with implications for health, biodiversity, and economic growth. has a rich history of traditional use for treating various ailments such as fever and diarrhea. Beyond its traditional uses, the plant's antioxidant properties suggest potential applications in combating oxidative stress-related conditions.

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Prostate cancer is a widespread malignancy among men, with a substantial global impact on morbidity and mortality. Despite advances in conventional therapies, the need for innovative and less toxic treatments remains a priority. Emerging evidence suggests that dietary plant metabolites possess epigenetic-modifying properties, making them attractive candidates for prostate cancer treatment.

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Article Synopsis
  • Chemotherapy remains the primary treatment for many cancers, but its effectiveness is limited by drug resistance often linked to lysosomal functions in cells.
  • Lysosomes play a dual role by sequestering chemotherapeutic drugs, thus lowering their availability and enhancing resistance; they also contribute to cancer progression through enzymatic activity and triggering cell death.
  • The review discusses mechanisms of lysosomal drug sequestration and explores strategies to target lysosomes, aiming to reverse drug resistance and improve cancer treatment outcomes.
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