The impact of speech rhythm and rate on comprehension in aphasia.

Background: Speech comprehension impairment in post-stroke aphasia is influenced by speech acoustics. This study investigated the impact of speech rhythm (syllabic isochrony) and rate on comprehension in people with aphasia (PWA). Rhythmical speech was hypothesised to support comprehension in PWA by reducing temporal variation, leading to enhanced speech tracking and more appropriate sampling of the speech stream.

Surface guided electron FLASH radiotherapy for canine cancer patients.

Background: During recent years FLASH radiotherapy (FLASH-RT) has shown promising results in radiation oncology, with the potential to spare normal tissue while maintaining the antitumor effects. The high speed of the FLASH-RT delivery increases the need for fast and precise motion monitoring to avoid underdosing the target. Surface guided radiotherapy (SGRT) uses surface imaging (SI) to render a 3D surface of the patient.

Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-Containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in Both Mice and Non-Human Primates.

Zaire ebolavirus, Sudan ebolavirus, and Marburg marburgvirus are the filoviruses most commonly associated with human disease. Previously, we administered a three-dose regimen of trivalent vaccines comprising glycoprotein antigens from each virus in mice and non-human primates (NHPs). The vaccines, which contained a polysorbate 80-stabilized squalane-in-water emulsion adjuvant and were lyophilized from a solution containing trehalose, produced high antibody levels against all three filovirus antigens.

Porcine and bovine Clostridium difficile ribotype 078 isolates demonstrate similar growth and toxigenic properties.

Clostridioides (C.) difficile are found in cows, pigs and poultry suggesting that this pathogen is present and more importantly animals could act as a reservoir, via food or environment, of human C. difficile infection.