Mechanical and microscopic characterization of expansive soils modified by water-soluble polymers.

With the advancement of ecological and environmental protection construction, the research on the modification of expansive soil using environmentally friendly polymers can make up for the harm to the ecological environment caused by traditional modification. Mechanical and microscopic properties of modified expansive soils were analyzed through indoor tests. The results showed that the liquid limit and plasticity index decreased by 52.

Seasonal Fluctuation in the Incidence of Congenital Hypothyroidism Across Different Temperate Zones of China.

Background: Seasonality in the incidence of congenital hypothyroidism (CH) has been identified in several countries and different conclusions have been drawn. The objective of this study was to examine whether this seasonality is also observable in China and how it manifests across different temperate zones.

Methods: Data on CH cases and screened neonates between January 1, 2014, and September 30, 2022, by year and season, were sourced from the Chinese Newborn Screening Information System.

Promotion of microfracture-mediated cartilage repair by the intra-articular injection of Mg2.

Aims: Magnesium ions (Mg) play an important role in promoting cartilage repair in cartilage lesions. However, no research has focused on the role of Mg combined with microfracture (MFX) in hyaline-like cartilage repair mediated by cartilage injury. This study aimed to investigate the beneficial effects of the combination of MFX and Mg in cartilage repair.

Detailed Structural Elucidation of Antibody-Drug Conjugate Biotransformation Species Using High Resolution Multiple Reaction Monitoring Mass Spectrometry with Orthogonal Dissociation Methods.

Antibody-drug conjugates (ADCs) are a promising drug modality substantially expanding in both the discovery space and clinical development. Assessing the biotransformation of ADCs and is important in understanding their stability and pharmacokinetic properties. We previously reported biotransformation pathways for the anti-B7H4 topoisomerase I inhibitor ADC, AZD8205, puxitatug samrotecan, that underpin its structural stability using an intact protein liquid chromatography-high resolution mass spectrometry (LC-HRMS) approach.