Publications by authors named "H R Slater"
Background: The emergence of -deleted parasites threatens histidine-rich protein 2 (HRP2)-based malaria rapid diagnostic test (RDT) performance. RDTs targeting () lactate dehydrogenase (LDH) may address current product limitations and improve case management.
Objectives: To evaluate the performance and usability of three LDH-based RDTs in febrile patients.
Using the Australiasian electronic Persistent Pain Outcomes Collaboration, a binational pain registry collecting standardized clinical data from paediatric ePPOC (PaedsePPOC) and adult pain services (AdultePPOC), we explored and characterized nationally representative chronic pain phenotypes and associations with clinical and sociodemographic factors, health care utilization, and medicine use of young people. Young people ≥15.0 and <25.
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- - The study investigated how long malaria rapid diagnostic tests (RDT) and ultra-sensitive RDT (uRDT) remained positive after treatment in a low transmission area in Namibia, finding an average positivity duration of 42 days for RDT and 67 days for uRDT.
- - Factors such as younger age, higher initial parasite density, and persistent parasitemia were linked to longer test positivity, indicating that the usual explanations for lingering positive results, like drug resistance, did not apply.
- - These prolonged positivity durations highlight challenges in using RDTs and uRDTs for accurately identifying current infections in low transmission settings, as they might reflect residual parasite DNA rather than active infection.