Management of the short bowel syndrome after extensive small bowel resection.

Short bowel syndrome (SBS) is a global malabsorption syndrome that results from extensive intestinal resections. It used to be a typical complication of repetitive bowel resections in patients with Crohn's disease. However, due to improved medical and surgical therapies for these patients it currently occurs more frequently as a consequence of vascular disorders in adults (intestinal infarction) and congenital aberrations in children, respectively.

Effects of tritiated uridine and tritiated histidine on survival of Chinese hamster cells at -196 degrees C.

Chinese hamster cells in vitro subjected to tritium disintegrations at -196 degrees C from incorporated tritiated uridine were more sensitive to decays occurring in the nucleus (Do = 1,610 decays/cell, equivalent to approximately 3.0 Gy to the nucleus) than to those occurring over the whole cell (Do = 3,240 decays/cell). A tritiated amino acid, 3H-histidine, gave a result (Do = 2,710 decays/cells) between nuclear 3H-uridine and whole cell 3H-uridine.

Chromosomal aberrations in Chinese hamster cells exposed in vitro to tritium-labelled thymidine or x-rays at--196 degrees C.

A comparison was made between the incidence of chromosomal aberrations in G2-phase first division Chinese hamster cells exposed to tritium labelled thymidine (dose range 54-522 rad) or to 250 kV X-rays (dose range 98-711 rad) at--196 degrees C. The dose-response relationship for chromatid aberrations, expressed as breaks per cell, appeared to be linear for intranuclear tritium whereas that for X-rays was curvilinear. For the dose range studied, cells exposed to X-rays were markedly less sensitive than tritium-incorporated cells where a transmutation effect may operate.