Publications by authors named "H R Noonan"
Article Synopsis
- * Researchers identified a specific gene, ID1, that plays a critical role in the transformation process by affecting gene expression and the morphology of melanocytes, indicating its contribution to the early stages of melanoma.
- * The study's findings suggest that there are clinically undetectable precursors to melanoma that exhibit distinct traits and that targeting these precursors could lead to improved methods for early diagnosis and prevention of the disease.
Article Synopsis
- Dysregulation of TGFb-related signaling pathways is a common feature in melanoma, leading to unique gene expression patterns in advanced stages of the disease.
- Researchers identified a specific TGFb enhancer active in melanoma cells, revealing that it is not present in normal or early melanoma cells but shows distinct expression in advanced melanomas.
- The study suggests that chronic TGFb signaling alters macrophage behavior and emphasizes the importance of developing biomarkers to improve patient responses to TGFb inhibitors.
Objective: To pilot surveillance to describe environmental, personal and behavioural risk factors for people presenting to hospital emergency departments (EDs) with heat illness.
Methods: We conducted a retrospective case series and telephone interview study of people presenting to EDs across South Western Sydney, Western Sydney and Nepean Blue Mountains Local Health Districts with heat illness over the 2017/18 and 2018/19 summer periods (1 December to 28 February). We used the Public Health Rapid Emergency Disease Syndromic Surveillance (PHREDSS) 'heat problems' syndrome to identify people with heat illness and medical records to find contact details.
Background: Palliative care (PC) for children with life-limiting conditions (LLC) is a holistic approach to achieve the best quality of life.
Aims: Highlighting collaboration between pediatric and PC services is essential in providing seamless care.
Methods: Retrospective data obtained including patient cohort, disease profile, place of death, and the resource requirements for children with a LLC in the Mid-West region of Ireland over a 7-year period.
Ultraviolet (UV) light and incompletely understood genetic and epigenetic variations determine skin color. Here we describe an UV- and microphthalmia-associated transcription factor (MITF)-independent mechanism of skin pigmentation. Targeting the mitochondrial redox-regulating enzyme nicotinamide nucleotide transhydrogenase (NNT) resulted in cellular redox changes that affect tyrosinase degradation.
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