Publications by authors named "H R Nash"

Background: Early in the coronavirus disease 2019 (COVID-19) pandemic, Sunda pangolins (Manis javanica) involved in the illegal wildlife trade in mainland China were identified as hosts of severe acute respiratory syndrome-related coronaviruses (SARSr-CoVs). Although it is unconfirmed whether pangolins or other traded wildlife served as intermediate hosts for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the trafficking of pangolins presents a clear risk for transmission of viruses with zoonotic and epizootic potential regardless. We have investigated the origins of pangolin carcasses seized in Hong Kong and have evaluated their potential exposure to SARSr-CoVs, other coronaviruses, and paramyxoviruses, aiming to address a gap in our knowledge with regard to the role of wildlife trade in the maintenance and emergence of pathogens with zoonotic and epizootic potential.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers have developed sulanemadlin (ALRN-6924), the first cell-permeable peptide to undergo clinical trials, designed to mimic the p53 tumor suppressor protein.
  • ALRN-6924 effectively binds to MDM2 and MDMX, which normally inhibit p53, thereby activating p53 signaling in non-mutant cells.
  • At higher doses, ALRN-6924 shows anticancer effects in tumor models, while lower doses can briefly halt the cell cycle in healthy cells to protect them during chemotherapy without affecting mutant cancer cells.
View Article and Find Full Text PDF

The Rose Report (Rose, Independent review of the primary curriculum (England); 2009) outlined a set of recommendations for the management of dyslexia in the United Kingdom after a range of issues were found. Despite these recommendations, recent reports indicate that issues are still prevalent in the diagnosis process and support offered for dyslexic children. The Delphi method was employed to gain parental consensus as to the most significant barriers to diagnosis and delivery of support for children with dyslexia, as well as solutions to overcoming these barriers.

View Article and Find Full Text PDF

Two recent computational models of reading development propose that irregular words are read using a combination of decoding and lexical knowledge but differ in assumptions about how these sources of information interact and about the relative importance of different aspects of lexical knowledge. We report developmental data that help to adjudicate these differences. Study 1 adopted a correlational approach to investigate the item-level relations between the ability to read a word aloud, general decoding ability, and knowledge of the word's phonological form (lexical phonology) or meaning (lexical semantics).

View Article and Find Full Text PDF

We present a series of auxiliary basis sets, for the elements Na to Ar, for use in density-fitted Hartree-Fock calculations with the correlation consistent cc-pV(n + d)Z orbital basis sets. Benchmarking on total molecular energies, reaction energies and the spectroscopic constants of the SO molecule demonstrate that the new sets address the deficiencies of using existing auxiliary sets in combination with these orbital basis sets. We also report auxiliary basis sets for Na and Mg matched to cc-pVnZ, along with recommendations for pairing auxiliary basis sets to the cc-pVnZ-F12 basis sets for Hartree-Fock calculations.

View Article and Find Full Text PDF