The study investigates the effect of smokeless tobacco (SLT) on the levels and activity of superoxide dismutase (SOD), a key antioxidant enzyme, in human saliva.
Researchers collected and compared saliva samples from 32 SLT users and 32 non-users, revealing that SOD activity is higher in SLT consumers initially, suggesting a compensatory response to oxidative stress.
Over time, as tobacco use continues, SOD levels decrease, indicating a decline in the body's defense against oxidative damage, which may contribute to the development of oral lesions and cancer.