Publications by authors named "H R MacDonald"
Background: Investment in scale-up and sustainment of effective health-promoting programs is often hampered by competing demands on scarce health dollars. Thus, optimizing programs to reduce resource use (e.g.
View Article and Find Full Text PDFThe rapid evolution of healthcare, driven by the rise of new health technologies and the growing emphasis on evidence-based care, requires health professionals skilled in assessing and utilizing evidence to support decision-making. Health technology assessments (HTAs), which involve evidence synthesis and appraisal, analysis across various domains, and tailoring evidence to local contexts, can develop these skills. These skills are also part of medical competencies.
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- There is considerable evidence suggesting that changes in dopamine signaling are linked to neuropsychiatric disorders like ADHD and other behavioral traits over the past 40 years.
- The review focuses on the key elements of dopamine signaling in the brain, particularly looking at enzymes, transporters, and receptors involved in this process, with a specific focus on areas related to ADHD.
- While dopamine is implicated in ADHD, there's limited support for the notion that a general lack of dopamine is the primary issue; future research should explore how dopamine interacts with other neurotransmitters and its role during brain development in different clinical subgroups.*
Background Extracapsular hip fractures are routinely treated with fixation, and the majority heal without complication. The fixation fails in a minority of cases, typically either by 'cutting out' of the superior femoral head or through breakage of the metalwork following non-union. In such cases, if operative treatment is thought appropriate, there are two major treatment options: revision fixation of the fracture or joint replacement surgery.
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