Publications by authors named "H R Holmes"
The chloride transporter-channel SLC26A9 is mediated by a reciprocal regulatory mechanism through the interaction between its cytoplasmic STAS domain and the R domain of CFTR. In vertebrate Slc26a9s, the STAS domain structures are interrupted by a disordered loop which is conserved in mammals but is variable in non-mammals. Despite the numerous studies involving the STAS domains in SLC26 proteins, the role of the disordered loop region has not been identified.
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- Deprescribing is essential for older adults, focusing on safe medication management, and effective communication is critical in this process.
- An international group of 14 experts created a framework to analyze how communication is utilized in deprescribing, identifying the need for more comprehensive approaches beyond just clinician-patient interactions.
- The research highlights missed opportunities for enhancing deprescribing communication at the community level and calls for further studies to determine the most effective communication strategies and styles for this process.
The field of therapeutic peptides is experiencing a surge, fueled by their advantageous features. These include predictable metabolism, enhanced safety profile, high selectivity, and reduced off-target effects compared with small-molecule drugs. Despite progress in addressing limitations associated with peptide drugs, a significant bottleneck remains: the absence of a large-scale in silico screening method for a given protein target structure.
View Article and Find Full Text PDFMany current gridded surface meteorological datasets are inadequate for quantifying near-surface spatiotemporal variability because they do not fully represent the impacts of land surface heterogeneity. Of note, explicit representation of the spatial structure and magnitude of local urban warming are usually lacking. Here we enhance the representation of spatial meteorological variability over urban areas in the conterminous United States (CONUS) by employing the High-Resolution Land Data Assimilation System (HRLDAS), which accounts for the fine-scale impacts of spatiotemporally varying land surfaces on weather.
View Article and Find Full Text PDFPurpose: A lack of representative human disease models has limited the translation of new and more effective treatments in uveal melanoma (UM), the most common primary adult intraocular malignancy. To fill this critical need, we developed and characterized a multicenter biobank of UM patient-derived organoids (PDOs).
Methods: UM patients requiring enucleation from 2019 to 2024 donated tumor tissue for PDO generation.