Publications by authors named "H R Hady"
The autoimmune disease systemic lupus erythematosus (SLE) is presented with many clinical symptoms. The transcription factor fork head box protein 3 (Foxp3) is expressed on regulatory T (T-reg) cells and essential for its development and function. Functional single-nucleotide polymorphisms (SNPs) in the Foxp3-3279 (rs3761548 C/A) gene influence SLE pathogenesis.
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- The study investigates the expression and functionality of follicle-stimulating hormone receptor (FSHR) in human myometrium (uterine muscle) and adipose tissue (fat) during both non-pregnant and pregnant states, as well as its connection to uterine activity and fat thermogenesis.
- Using various methods to evaluate FSHR expression and treatment effects, the researchers found no FSHR expression in these tissues, contradicting prior studies.
- The results indicate that FSHR signaling does not play a role in regulating uterine contraction or influencing adipose tissue activities, casting doubt on previous assumptions about FSHR's functionality in these areas
Purpose: Neoadjuvant chemotherapy (NACT) improves muscle-invasive bladder cancer (MIBC) survival. However, its efficacy is limited to a group of patients. This study explored CK5/6 and GATA3 for molecular subtyping and their prediction to response in patients with MIBC.
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- Preterm infants often experience feeding intolerance due to their immature digestive systems, which can lead to increased risks of complications.
- A study was conducted to evaluate the effects of oral bovine lactoferrin (LF) supplementation on feeding intolerance and intestinal health in these infants, using a randomized double-blind design with 60 preterm neonates.
- Results showed that infants receiving lactoferrin achieved full feeding sooner (9 days vs. 15 days) and had lower serum zonulin levels, indicating improved intestinal permeability and feeding tolerance compared to the control group.
Phloroglucinol (PHG), an analgesic and spasmolytic drug, shows promise in preventing high-fat-diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) and insulin resistance. In Wistar rats, 10 weeks of PHG treatment did not prevent HFD-induced weight gain but significantly mitigated fasting hyperglycemia, impaired insulin responses, and liver steatosis. This protective effect was not linked to hepatic lipogenesis or AMP-activated protein kinase (AMPK) activation.
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