Publications by authors named "H R Guy"
Article Synopsis
- The U.S. COVID-19 vaccination program started in December 2020 and has played a crucial role in reducing illness and death caused by the virus, with safety monitoring being a key part of this effort.
- The government established multiple safety monitoring systems, utilizing both passive and active surveillance to track potential adverse events, especially focusing on vulnerable groups like pregnant individuals.
- The report highlights how systems worked together to quickly identify and manage issues like myocarditis after mRNA vaccinations, ensuring effective communication of safety data to healthcare providers and the public.
To review safety and efficacy outcomes in studies of first-line maintenance therapies for advanced ovarian cancer. A systematic literature review was performed (27 February 2020) to identify clinical outcomes including progression-free survival (PFS), overall survival (OS) and Grade ≥3 adverse events. Overall 50 references met prespecified criteria; 18 studies evaluated 10 different agents, including PARP inhibitors.
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- Selecting a first-line maintenance option for ovarian cancer is difficult due to the variety of therapies and lack of direct comparisons between different treatments.
- This study evaluated the feasibility of indirect treatment comparisons (ITCs), specifically a network meta-analysis (NMA) and a population-adjusted ITC (PAIC), to assess the efficacy of the PARP inhibitor niraparib in comparison to other treatments.
- The results showed that neither ITC was viable due to significant differences in trial designs and patient criteria, indicating that such comparisons should be approached with caution, as they may not provide reliable evidence for treatment decisions.
Amyloid beta (Aβ) peptides are a major contributor to Alzheimer's disease. They occur in differing lengths, each of which forms a multitude of assembly types. The most toxic soluble oligomers are formed by Aβ42; some of which have antiparallel β-sheets.
View Article and Find Full Text PDFAmyloid beta (Aβ of Alzheimer's disease) and α-synuclein (α-Syn of Parkinson's disease) form large fibrils. Evidence is increasing however that much smaller oligomers are more toxic and that these oligomers can form transmembrane ion channels. We have proposed previously that Aβ42 oligomers, annular protofibrils, and ion channels adopt concentric β-barrel molecular structures.
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