Publications by authors named "H R Etheredge"
Article Synopsis
- - The Generation Study (GS) aims to recruit 100,000 newborns in England to utilize whole genome sequencing for early detection and treatment of rare conditions, while also exploring lifelong genome storage and the complexities involved in newborn consent and genomic medicine research.
- - Over two years, the GS team conducted 9 rounds of Design Research with 105 expectant and recent parents to co-design and test consent materials, uncovering challenges and facilitators in the consent process.
- - Involving parents in the design process has enriched understanding of informed decision-making for genome sequencing, suggesting that continuous research and design iterations can enhance how consent materials are crafted and communicated.
Pharmaceutical companies subject all new molecular entities to a series of in vitro metabolic characterizations that guide the selection and/or design of compounds predicted to have favorable pharmacokinetic properties in humans. Current drug metabolism research is based on liver tissue predominantly obtained from people of European origin, with limited access to tissue from people of African origin. Given the interindividual and interpopulation genomic variability in genes encoding drug-metabolizing enzymes, efficacy and safety of some drugs are poorly predicted for African populations.
View Article and Find Full Text PDFThe COVID-19 pandemic posed an unprecedented challenge to modern bioethical frameworks in the clinical setting. Now, as the pandemic stabilises and we learn to 'live with COVID', the medical community has a duty to evaluate its response to the challenge, and reassess our ethical reasoning, considering how we practise in the future. This article considers a number of clinical and bioethical challenges encountered by the author team and colleagues during the most severe waves of the pandemic.
View Article and Find Full Text PDFBackground: Data on colorectal cancer (CRC) diagnosis to treatment interval (DTI), an index of quality assurance in high-income countries (HICs) is lacking in South Africa. This study aimed to determine DTIs and their impact on CRC survival in a South African cohort.
Methods: Participants ( = 289) from the Colorectal Cancer in South Africa (CRCSA) cohort were identified for inclusion.
Background: Although the experience of hospitalisation for cancer management has been widely researched, such research from the African sub-continent is limited.
Objective: This study explored experiences of patient care in a tertiary, inpatient oncology setting in urban South Africa, from the point of view of patients and health professionals.
Methods: In-depth interviews and focus groups were conducted with participants.