Publications by authors named "H R Dalton"
Background: Prone positioning of patients with COVID-19 undergoing invasive mechanical ventilation (IMV) is widely used, but evidence of efficacy remains sparse. The COVID-19 Critical Care Consortium has generated one of the largest global datasets on the management and outcomes of critically ill COVID-19 patients. This prospective cohort study investigated the association between prone positioning and mortality and in particular focussed on timing of treatment.
View Article and Find Full Text PDFBackground: Critical care of patients on extracorporeal membrane oxygenation (ECMO) with acute brain injury (ABI) is notable for a lack of high-quality clinical evidence. Here, we offer guidelines for neurological care (neurological monitoring and management) of adults during and after ECMO support.
Methods: These guidelines are based on clinical practice consensus recommendations and scientific statements.
Article Synopsis
- DPAGT1-CDG is a genetic disorder caused by mutations in the DPAGT1 gene, leading to issues in the body's glycosylation processes and currently lacking effective treatments.
- A study used a fruit fly model with eye defects to screen over 1,500 FDA-approved drugs, resulting in the identification of 42 candidates that improved the eye phenotype.
- Among these, targeting the dopamine D2 receptor showed promise, indicating a link between dopamine signaling and N-glycosylation, while other drug categories, like acetylcholine drugs and COX inhibitors, may also offer new therapeutic possibilities for DPAGT1-CDG.