Publications by authors named "H R Choudhury"

Introduction: Scaphoid fractures are one of the most common carpal bone fractures, with most fractures involving the waist. When surgery is indicated, internal fixation with screws is the standard method for the fixation of these fractures. Accurate length and trajectory of the screw are two crucial parameters essential for optimal internal fixation.

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  • The malaria parasite can alter its transcriptome to resist the effects of drugs, particularly affecting multigene families.
  • CDPK family protein kinases in Plasmodium falciparum are crucial for its development and are potential targets for anti-malarial drugs.
  • By using a chemical genetics approach to study a mutant parasite with a modified cdpk1 gene, researchers aim to discover compensatory mechanisms that could be targeted to combat drug resistance.
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Rhabdomyolysis (RM) is characterised by the breakdown of skeletal muscle tissue, releasing toxic intracellular components into circulation. It presents with dark urine, muscle weakness, myalgia, and elevated creatine phosphokinase levels (CPK). Drug-induced RM is aetiologically significant.

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Conditional regulation is a highly beneficial system for studying the function of essential genes in Plasmodium falciparum and dimerizable Cre recombinase (DiCre) is a recently adapted conditional regulation system suitable for this purpose. In the DiCre system, two inactive fragments of Cre are reconstituted to form a functionally active enzyme in the presence of rapamycin. Different loci have been targeted to generate parasite lines that express the DiCre enzyme.

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  • Protozoan parasitic diseases are a big health problem around the world, so scientists need to learn how they work to create better vaccines and medicines.
  • New tools like CRISPR/Cas9 make it faster and easier to change the genes of these parasites compared to older methods, which took a long time.
  • This chapter talks about how CRISPR/Cas9 is being used to study different parasites like Plasmodium, Leishmania, and Trypanosoma, helping us understand their biology, drug resistance, and how to diagnose infections.
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