Hyperspectral measurements of light backscattering by particles in water with a fixed angle setup: proof of concept and instrument calibration.

The light backscatter signal is the fraction of light scattered at angles greater than 90 degrees with respect to the direction of the incident light. Optical remote sensing platforms collect this signal, which, when measured from the ocean, holds crucial information about its constituents. Interpretation of this signal demands a rigorous understanding of scattering by water and by particles in water.

Ruthenium Complex HB324 Induces Apoptosis via Mitochondrial Pathway with an Upregulation of Harakiri and Overcomes Cisplatin Resistance in Neuroblastoma Cells In Vitro.

Ruthenium(II) complexes with N-heterocyclic carbene (NHC) ligands have recently attracted attention as novel chemotherapeutic agents. The complex HB324 was intensively studied as an apoptosis-inducing compound in resistant cell lines. HB324 induced apoptosis via mitochondrial pathways.

Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PL.

The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are commonly underrepresented in compound libraries that are used for screening in drug discovery campaigns, however, there is growing evidence for their role in medicinal chemistry. Based on previous results, we have selected more than 100 structurally diverse metal complexes for profiling as inhibitors of two relevant SARS-CoV-2 replication mechanisms, namely the interaction of the spike (S) protein with the ACE2 receptor and the papain-like protease PL .

Autonomous Collision Avoidance at Sea: A Survey.

In this survey, results from an investigation on collision avoidance and path planning methods developed in recent research are provided. In particular, existing methods based on Artificial Intelligence, data-driven methods based on Machine Learning, and other Data Science approaches are investigated to provide a comprehensive overview of maritime collision avoidance techniques applicable to Maritime Autonomous Surface Ships. Relevant aspects of those methods and approaches are summarized and put into suitable perspectives.

Evaluation of Ruthenium(II) -Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase.

A series of ruthenium(II) complexes with -heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(II)X (where X = halide) was prepared, characterized, and evaluated as antibacterial agents in comparison to the respective metal free benzimidazolium cations. The ruthenium(II) NHC complexes generally triggered stronger bacterial growth inhibition than the metal free benzimidazolium cations. The effects were much stronger against Gram-positive bacteria ( and ) than against Gram-negative bacteria (,  , ), and all complexes were inactive against the fungus .