Publications by authors named "H Quigley"
Article Synopsis
- The study aimed to measure biomechanical strains in the lamina cribrosa of human eyes during increases in intraocular pressure (IOP) using optical coherence tomography (OCT) imaging.
- After applying swim goggles to raise IOP, significant strains were observed in glaucoma patients, with increases linked to worse visual function and complications.
- The findings suggest that biomechanical responses in the optic nerve head could serve as a noninvasive biomarker for assessing glaucoma damage.
Article Synopsis
- The study aimed to explore how topical 2% ripasudil (a Rho kinase inhibitor) protects the nervous system, specifically looking at retinal ganglion cell (RGC) loss in mice exposed to increased intraocular pressure (IOP) and optic nerve damage.
- Results showed that ripasudil significantly reduced RGC axon and soma loss compared to saline-treated controls, indicating its protective effects against nerve damage.
- The findings suggest that ripasudil works by suppressing ROCK signaling pathways in the retina and optic nerve, affecting both RGCs and astrocyte responses to elevated IOP.
Objective: To measure mechanical strain of the lamina cribrosa (LC) after intraocular pressure (IOP) change produced 1 week after a change in glaucoma medication.
Design: Cohort study.
Participants: Adult glaucoma patients (23 eyes, 15 patients) prescribed a change in IOP-lowering medication.