Comparison of the antidepressant action of tryptophan, tryptophan/5-hydroxytryptophan combination and nomifensine.

To check the hypothesis that combined treatment with tryptophan and 5-hydroxytryptophan is superior to the administration of tryptophan on its own we studied three groups of 8 patients. One group received tryptophan, the second a tryptophan/5-hydroxytryptophan combination and the third low-dose nomifensine as a control. The trial was performed in the double-blind mode, under strictly standardized conditions, with behavioural therapy and a structured daily routine.

[Diagnostic value of electrophysiologic studies in presenile and senile dementia].

From the therapeutical point of view, reliable differentiations of different dementia types are required. Electrophysiological methods could be advantageous for this purpose. Healthy elderly people already show slight EEG-changes as slower alpha rhythm with decreased percent time and amplitude, furtheron temporal foci predominantly on the left side.

[Drug-response differences of high and standard dosage of fluphenazine-decanoate in relation to schizophrenic symptoms (author's transl)].

The treatment of schizophrenic patients with high-dosed neuroleptics is discussed. The drug-response difference between a low dose and a high dose of Fluphenazine-Decanoate was investigated in 40 chronic schizophrenic patients. All patients were resistant to standard doses of neuroleptics and were therefore treated with higher doses.

[Changes in the oxidative glucose brain metabolism under long-term xantinol-nicotinate medication (author's transl)].

8 patients suffering from dementia were treated with xantinol-nicotinate for 4 weeks. At the beginning and at the end of the treatment cerebral blood flow and cerebral metabolic rates of oxygen, glucose and lactate were measured with the N2O-method. With regard to the initial level of each parameter CBF, CMR glucose and CMR oxygen increased significantly, if it had been decreased at the first measurement, while primarily normal or even increased parameters did not change.