EFFECT OF COMPREHENSIVE DENTAL TREATMENT UNDER GENERAL ANAESTHESIA ON CHILDREN'S ORAL-HEALTH-RELATED QUALITY OF LIFE: A COMPARATIVE CROSS-SECTIONAL STUDY.

Background: Despite reductions in dental caries experience in developed countries, early childhood caries remains the most prevalent health problem in developing countries. This has a direct impact on the oral health-related quality of life of both children and parents. The objective of this study was to examine the impact of comprehensive dental treatment under general anaesthesia on oral health-related quality of life in children, using a parental and caregiver perception questionnaire.

Delivery of encapsulated bioactive compounds within food matrices to the digestive tract: recent trends and future perspectives.

Encapsulation technologies have achieved encouraging results improving the stability, bioaccessibility and absorption of bioactive compounds post-consumption. There is a bulk of published research on the gastrointestinal behavior of encapsulated bioactive food materials alone using and digestion models, but an aspect often overlooked is the impact of the food structure, which is much more complex to unravel and still not well understood. This review focuses on discussing the recent findings in the application of encapsulated bioactive components in fabricated food matrices.

Practical Characterization Strategies for Comparison, Qualification, and Selection of Cell Viability Detection Methods for Cellular Therapeutic Product Development and Manufacturing.

Cellular therapy development and manufacturing has focused on providing novel therapeutic cell-based products for various diseases. The International Organization for Standardization (ISO) has provided guidance on critical quality attributes (CQAs) that shall be considered when testing and releasing cellular therapeutic products. Cell count and viability measurements are two of the CQAs that are determined during development, manufacturing, testing, and product release.

A rapid and high-throughput T cell immunophenotyping assay for cellular therapy bioprocess using the Cellaca® PLX image cytometer.

In cellular therapies chimeric antigen receptor (CAR) T or NK cells undergo phenotypic analysis at multiple stages during discovery and development of novel therapies. Patient samples are routinely analyzed via flow cytometry for population identification and distribution of CD3, CD4, and CD8 positive T cells. As an alternative or orthogonal method, image cytometry systems have been used to perform simple cell-based assays in lieu of flow cytometry.