Acetylcholinesterase and HHV-8 in squamous cell carcinoma and retinoblastoma.

Acetylcholinesterase (AChE) and human herpesvirus type 8 (HHV-8) antigens were studied in tissue sections from 56 squamous cell carcinomas (SCC) and five retinoblastomas (Rb). Approximately 62.5% of SCC and 80% of Rb showed positive staining for AChE.

In vitro Inhibition of HHV-6 replication by sophocarpines.

The virostatic activity of sophocarpines and gancyclovir (GCV) was tested using HHV-6 Z29 strain and Molt-3 cells. The cytotoxic (IC(50)) and the antiviral (ED(50)) values were first experimentally determined and selective indices (SI) were then calculated. The SI values for sophocarpines 1 and 2 and GCV were in the order 184, 183, and 23, respectively.

Frequency of occurrence of cytomegalovirus and Chlamydia pneumoniae in lymphocytes of atherosclerotic patients.

Forty-three blood samples from atherosclerotic donors and 28 samples from normal individuals were analyzed to determine the frequency of occurrence of cytomegalovirus (CMV) and Chlamydia pneumoniae DNA sequences in lymphocytes of Saudi Arabian donors using Polymerase Chain Reaction (PCR). In non-atherosclerotic donors, no CMV DNA was detectable and only one sample was positive for C-pneumoniae DNA sequences. Of the 43 atherosclerotic patients, 22 were infected with CMV, 23 were infected with C-pneumoniae and 11 showed no infection.

Frequency of coexistence of cytomegalovirus and Chlamydia pneumoniae in atherosclerotic plaques.

Background: Cytomegalovirus (CMV) and Chlamydia pneumoniae (C. pneumoniae) antigens and DNA sequences have been demonstrated in atherosclerotic plaques by several investigators. Most significantly, CMV DNA was found both in atherosclerotic lesions as well as in uninvolved areas of aortas and carotid artery, whereas C.

Possible role of HHV-6 in the enhanced severity of HSV-1 keratitis.

Rabbits were divided into three groups and infected with Human Herpesvirus Type 6 (HHV-6) or Herpes Simplex Virus Type 1 (HSV 1). Infected eyes were swabbed and cultured every alternate day. At day 15 postinfection (PI), rabbits were sacrificed, trigeminal ganglia (TG) and corneas were analyzed for the presence or absence of viral DNA.