A prediction model for electrical strength of gaseous medium based on molecular reactivity descriptors and machine learning method.

Context: Ionization and adsorption in gas discharge are similar to electrophilic and nucleophilic reactions. The molecular descriptors characterizing reactions such as electrostatic potential descriptors are useful in predicting the electrical strength of environmentally friendly gases. In this study, descriptors of 73 molecules are employed for correlation analysis with electrical strength.

Rapid pesticide residues detection by portable filter-array hyperspectral imaging.

The detection of pesticide residues in agricultural products is crucial for ensuring food safety. However, traditional methods are often constrained by slow processing speeds and a restricted analytical scope. This study presents a novel method that uses filter-array-based hyperspectral imaging enhanced by a dynamic filtering demosaicking algorithm, which significantly improves the speed and accuracy of detecting pesticide residues.

PCBP2-dependent secretion of miRNAs via extracellular vesicles contributes to the EGFR-driven angiogenesis.

The EGFR-driven angiogenesis is crucial in solid tumors, particularly through the delivery of biomolecules via extracellular vesicles (EVs), but the mechanism by which EGFR regulates EV cargo is still unclear. First, cell co-culture and murine tumor models were employed to examine the impact of EGFR overexpression on the pro-angiogenic properties of small EVs (sEVs) derived from oral squamous cell carcinoma (OSCC). Small RNA sequencing was then used to compare the miRNA profiles of OSCC-sEVs with and without EGFR overexpression, followed by functional enrichment and motif analyses of the differentially expressed miRNAs.

Metabolic Engineering of BL21(DE3) for 2'-Fucosyllactose Synthesis in a Higher Productivity.

2'-Fucosyllactose (2'-FL) is the most abundant human milk oligosaccharides (HMOs). 2'-FL exhibits great benefits for infant health, such as preventing infantile diarrhea and promoting the growth of intestinal probiotics. The microbial cell factory technique has shown promise for the massive production of 2'-FL.

Nedd4 family interacting protein 1 directly regulates the NF-κB signaling pathway without promoting the ubiquitination of Tak1 in Nile tilapia.

Mammalian Nedd4 family interacting protein 1 (Ndfip1) serves as an activator of the E3 ubiquitin ligase, promoting ubiquitination and limiting the production of pro-inflammatory cytokines. However, the functional role of teleost Ndfip1 is not completely understood. In the current study, an Ndfip1 gene designated as OnNdfip1 was characterized in Nile tilapia.