Publications by authors named "H Poulet"
In the human and veterinary fields, oral vaccines generate considerable interest. In dogs, these vaccines are newly developed, and understanding their mechanisms is crucial. Mesenteric lymph nodes (MLNs) and Peyer's patches (PPs) are important sites for gastrointestinal mucosal induction, yet canine MLNs lack sufficient information.
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- Oral vaccination is effective for stimulating immune responses, with GALT and Peyer's patches being key players; however, our knowledge about these systems in dogs is still limited.
- The research involved advanced techniques like immunofluorescence, flow cytometry, and single-cell RNA sequencing to study canine Peyer's patches and their immune cell populations.
- The development of a specific antibody targeting canine M cells will assist in understanding how antigens enter the dog's GALT, providing insights for future studies on dog immune responses and diseases.
(Bb) is a Gram-negative bacterium responsible for canine infectious respiratory disease complex (CIRDC). Several vaccines targeting this pathogen are currently licensed for use in dogs, but their mechanism of action and the correlates of protection are not fully understood. To investigate this, we used a rat model to examine the immune responses induced and the protection conferred by a canine mucosal vaccine after challenge.
View Article and Find Full Text PDFFeline morbillivirus (FeMV) is a recently discovered virus belonging to the genus of the virus family . Often, the virus has been detected in urine of cats with a history of urinary disease and has a worldwide distribution. Currently, it is unclear which receptor the virus uses to enter the target cells.
View Article and Find Full Text PDFLeptospirosis is a vaccine-preventable bacterial zoonotic disease caused by pathogenic Leptospira species. The efficacy of canine vaccines is assessed by challenging vaccinated and control dogs with virulent serovars of , followed by detection of in blood and urine. We assessed the consistency between results obtained for urine and blood samples from clinical studies with species-specific real-time quantitative PCR (qPCR) targeting the gene and those obtained with the reference culture method.
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