[The antihypertensive effect of isradipine and additional pharmacodynamic effects].

The authors demonstrated that isradipine reduces the blood pressure assessed at rest in patients with mild to medium severe hypertension. The antihypertensive action was enhanced by administration of beta-blockers. In a loading test the pressor response to strain was reduced in particular as regards diastolic pressure; from this in may be concluded indirectly that a vasodilatating effect is involved.

Effects of premaxillary setback and of prolongation of the columella on the configuration of the facial profile in complete bilateral cleft lip and palate.

Roentgen-cephalometric studies were carried out in 26 adult males with complete bilateral cleft lip and palate. They were subdivided two times in two subgroups, with and without premaxillary setback, and with and without prolongation of the columella. The subgroups were compared mutually, as well as with a group of controls including 50 males matched in age.

Configuration of facial profile in adults with isolated cleft palate.

X-ray cephalometry was used for the assessment of the configuration of the skeletal and soft tissue profile in 81 adult males with isolated cleft palate. They were assessed in three subgroups, i. e.

Configuration of facial profile in adults with cleft lip with or without cleft palate.

X-ray cephalometric studies were carried out in 114 adult males with cleft lip and with or without cleft palate. According to the type and extent of the cleft they were subdivided into 4 groups and were compared with a control group of 50 normal males matched in age. Investigated were the parameters of the skeletal and soft facial profile.

Isradipine in the treatment of hypertension. Some additional effects observed during a one-year study.

After a placebo run-in phase of four weeks' duration, 1.25 mg or 2.5 mg isradipine twice daily orally was administered for one year to 23 patients who had been diagnosed as hypertensive.