Clinical validation of the Roche cobas HPV test on the Roche cobas 6800 system for the purpose of cervical screening and qualification as a second-generation comparator test.

This study assessed the relative clinical sensitivity and specificity for cervical precancer of the Roche cobas HPV test when processed using the Roche cobas 6800 system using the Roche cobas 4800 HPV test as comparator. Intra- and inter-laboratory reproducibility were evaluated as well. The cobas HPV test run on the cobas 6800 platform demonstrated a relative clinical sensitivity of 1.

Foodweb dynamics affect arsenic speciation and bioaccumulation in lakes affected by gold mines.

We investigated the bioaccumulation patterns of arsenic species in freshwater food webs from three lakes near historical mining operations in the Northwest Territories, Canada. Two of these lakes (Long Lake and Lower Martin Lake) were located within 5 km of the mine's roaster stacks, while a third lake (Small Lake), situated 27 km away, served as a far-field reference site. In each lake, we measured the concentrations of arsenic species, including As(III), As(V), MMA, DMA and organic arsenobetaine, AsB, across multiple environmental and biological compartments, including water, sediment, macrophytes, periphyton, phytoplankton, zooplankton, benthic invertebrates, and small- and large-bodied fish.

Is there an association between retinal vein occlusion and cerebrovascular accident? A systematic review and meta-analysis.

Background: Retinal vein occlusion (RVO) is a significant retinal vascular disorder that has been hypothesized to increase the risk of cerebrovascular accidents (CVA). Given the shared vascular pathology between the retina and cerebral circulation, understanding the association between RVO and stroke incidence is critical for early intervention and risk management. This systematic review and meta-analysis aim to evaluate the risk of CVA, including ischemic and hemorrhagic subtypes, in patients with RVO.

"This is life": An interpretative phenomenological analysis of the lived experience of working-age adults with inherited retinal diseases in Singapore.

Background: Inherited retinal diseases (IRDs) are a heterogeneous group of genetic disorders that progressively impair vision, affecting millions globally. Despite advancements in gene therapy, treatment options remain limited. The impact of IRDs on patients' psychological and social well-being, however, remains underexplored, especially in Asia.

Disparities of Aspirin Administration for Prehospital Chest Pain and ST Elevation Myocardial Infarctions.

Objectives: Although disparities exist in aspirin administration for chest pain and ST elevation myocardial infarctions (STEMI), little is known about community-based disparities in aspirin administration for prehospital patients. We evaluated disparities in prehospital aspirin using a national prehospital database.

Methods: We conducted a retrospective analysis of the 2018-2021 NEMSIS database linked to census data, including adult prehospital encounters.